The oxygen free radical system: Potential mediator of myocardial injury
نویسندگان
چکیده
منابع مشابه
Myocardial ischemia, reperfusion and free radical injury.
Reperfusion of coronary arteries to limit myocardial ischemic injury and extent of myocardial necrosis is possible by either the use of fibrinolytic therapy, coronary angioplasty or coronary artery bypass surgery. The concept that early reperfusion may salvage jeopardized myocardium is derived from basic experimental studies which purported to demonstrate that the ultimate extent of irreversibl...
متن کاملA STUDY OF FREE RADICAL INJURY TO VITAL ORGANS
The study of toxicities which are caused by free radical inducing chemicals (e.g., carbon tetrachloride), helps to determine the mode of action of those important drugs which act by inhibiting free radicals. Evaluation of toxicities induced by carbon tetrachloride and phenobarbitone administration was carried out in seventy healthy male rabbits. Each animal received CCI4 0.25-0.5 mL/kg bod...
متن کاملTransferrin: a potential source of iron for oxygen free radical-mediated endothelial cell injury.
The ability of transferrin to potentiate oxygen free radical-mediated endothelial cell injury was assessed. 51Cr-labeled endothelial cells derived from rat pulmonary arteries (RPAECs) were incubated with hydrogen peroxide (H2O2) in the presence and absence of holosaturated human transferrin, and the effect of transferrin on H2O2-mediated endothelial cell toxicity was determined. Addition of hol...
متن کاملHyperoxia causes oxygen free radical-mediated membrane injury and alters myocardial function and hemodynamics in the newborn.
Newborn children can be exposed to high oxygen levels (hyperoxia) for hours to days during their medical and/or surgical management, and they also can have poor myocardial function and hemodynamics. Whether hyperoxia alone can compromise myocardial function and hemodynamics in the newborn and whether this is associated with oxygen free radical release that overwhelms naturally occurring antioxi...
متن کاملRecipient of 1987 Fellowship Award in Cardiovascular Perfusion Age Related Differences in Oxygen Free Radical Injury during Myocardial Ischemia
_____________________________ __ (J. Extra-Corpor. Techno/. 19[3] p. 245-257 Fall 1987, 42 ref.) Myocardial protection with an oxygenated cardioplegic solution was studied in mature and immature animals. Isolated adult and neonatal rabbit hearts were exposed to 90 minutes of hypothermic 30°C ischemia, and one of the following treatments: multidose oxygenated (p02>650 torr) cardioplegia, multido...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1985
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(85)80278-3